Chrome Extension
WeChat Mini Program
Use on ChatGLM

Mitochondrion Journal

Papers
Magnetic resonance spectroscopy (MRS) has been utilized to study several metabolic pathways in vivo and in live tissues in vitro non-invasively. Despite its inherited lack of sensitivity, its application has extended all the way to in situ human tissues and organs since proper te...
Cited8Views6
8
6
Download
BibtexChatPaperRate
Synonymous codon changes may not always be neutral indicating their significance in disease association studies, which is almost always overlooked. Synonymous substitutions may affect protein-folding rates leading to protein misfolding and aggregation. Genome wide analysis of 230...
Cited6Views7
6
7
Download
BibtexChatPaperRate
S Santosh, K Pawan,P Karpagam, A Kaushala,P Neela
Mitochondria play a pivotal role in cellular metabolism, especially in energy production. Myocardial function depends on adenosine triphosphate (ATP) supplied by oxidation of several substrates. In the adult heart, this energy is obtained primarily from fatty acid oxidation throu...
Cited15Views10
15
10
Download
BibtexChatPaperRate
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane regulator (CFTR) gene and is the most common life-shortening genetic defect in Caucasians. Life expectancy in CF has improved substantially during the past 75 years because of treat...
Cited0Views4
0
4
Download
BibtexChatPaperRate
Linda Martin, Alan Redd, David Melvin, John Fratti
The relation between the use of disease modifying therapies (DMT׳s) and the occurrence of comorbid autoimmune diseases (AID׳s) in multiple sclerosis (MS) patients is still unclear.To investigate the difference in duration from MS symptom onset to first reported AID in subjects us...
Cited0Views0
0
0
Download
BibtexChatPaperRate
We investigated the biogenesis and mitochondrial antioxidant capacity of cytochrome c oxidase (COX) within the skeletal muscle under the treatments of p53 inhibitors (pifithrin, PFTα and PFTμ). Significantly, PFTμ increased mtDNA content and COX biogenesis. These changes coincide...
Cited2Views8
2
8
Download
BibtexChatPaperRate
Several gene transcription regulators considered solely localized within the nuclear compartment are being reported to be present in the mitochondria as well. There is growing interest in the role of mitochondria in regulating cellular metabolism in normal and disease states. Var...
Cited22Views1
22
1
Download
BibtexChatPaperRate
Proteins embedded in the inner mitochondrial membrane (IMM) perform essential cellular functions. Maintaining the folding state of these proteins is therefore of the utmost importance, and this is ensured by IMM chaperones and proteases that refold and degrade unassembled and mis...
Cited16Views0
16
0
Download
BibtexChatPaperRate
Nucleoside reverse transcriptase inhibitors (NRTIs) in highly active antiretroviral therapy (HAART) bring serious side effects to light. Mitochondrial dysfunction, mtDNA replication defects and mtDNA depletion in target tissues are observed experimentally and clinical confirmatio...
Cited22Views0
22
0
Download
BibtexChatPaperRate
As a signaling scaffold, p62/sequestosome (p62/SQSTM1) plays important roles in cell signaling and degradation of misfolded proteins. While localization of p62 to mitochondria has been reported, a description of its function once there, remains unclear. Here, we report that p62 i...
Cited0Views6
0
6
Download
BibtexChatPaperRate