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    • Rational Pharmacotherapy in Cardiology Journal

    Papers
    PROBLEMS OF EVALUATING BLOOD PRESSURE MEASUREMENT IN MODERN CLINICAL TRIALS (THE CASE OF SPRINT STUDY RESULTS)
    V. M. Gorbunov
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2018）
    The article presents a critical analysis of the results of a large clinical trial SPRINT. The focus is on the issues related to the blood pressure (BP) measurement in this trial. The aim of SPRINT trial was to prove the benefit of reducing systolic BP (SBP) below 120 mm Hg in hig...
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    COMPARATIVE EVALUATION OF THE ANTIHYPERTENSIVE EFFECT OF PERINDOPRIL AND LOSARTAN POTASSIUM IN PATIENTS WITH ARTERIAL HYPERTENSION AND STENOTIC CORONARY ATHEROSCLEROSIS BEFORE REVASCULARIZATION: AN OPEN RANDOMIZED COMPARATIVE STUDY
    O. A. Osipova, N. N. Kurbakov, A. G. Ovsyannikov,M. A. Vlasenko
    Rational Pharmacotherapy in Cardiology（2011）
    Aim. To compare effects of perindopril and losartan potassium on the parameters of the ambulatory blood pressure (BP) monitoring (ABPM) and circadian BP profile in patients with arterial hypertension (HT) and stenotic coronary atherosclerosis before myocardium revascularization. ...
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    Dynamics of 6-Minute Walk Distance As a Predictor of Efficiency Specific Pulmonary Vasodilators
    A. A. Shmalts
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2022）
    Pulmonary hypertension is a severe and often rapidly progressive disease with a fatal outcome. Approved specific therapy with five classes of drugs – prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors, soluble guanylate cyclase stimulators and prostacycl...
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    Heart Rate-Lowering Therapy in the Treatment of Chronic Heart Failure
    S. V. Shalaev, L. V. Silicic,O. V. Abaturova
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2015）
    Aspects of heart rate-lowering therapy in patients with chronic heart failure using If-channel blocker ivabradine are discussed. The evidence-based data on ivabradine use reveal its advantages, disadvantages and place in the treatment of cardiac patients.
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    CHANCE TO SURVIVE
    N. V. Dolgushina
    Rational Pharmacotherapy in Cardiology（2016）
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    URAPIDIL IN THE TREATMENT OF MEDICAL EMERGENCIES CAUSED BY BLOOD PRESSURE INCREASE
    N. I. Gaponova,V. R. A. Bdrakhmanov,S. N. Tereschenko
    Rational Pharmacotherapy in Cardiology（2012）
    Results of experimental and clinical studies devoted to urapidil combining central antihypertensive effect with peripheral vasodilatation are discussed. Scope of urapidil application is described; its good tolerability and safety are highlighted. Urapidil mode of application in d...
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    High Residual Platelet Reactivity During Dual Antiplatelet Therapy, Found by Optical Aggregometry and the Rate of Atherothrombotic Complications after Coronary Artery Stenting in Patients with Ischemic Heart Disease in Clinical Practice
    N. F. Puchinyan,N. V. Furman,P. V. Dolotovskaya,L. I. Malinova
    Racionalʹnaâ farmakoterapiâ v kardiologii（2016）
    Aim. To study the prevalence of high residual platelet reactivity (HRPR) during the dual antiplatelet therapy (DAT) with acetylsalicylic acid (ASA) and clopidogrel by optical aggregometry in patients with ischemic heart disease (IHD) after percutaneous transluminal coronary angio...
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    CLINICAL ADVANTAGES OF TELMISARTAN: FEATURES OF PHARMACOKINETICS, PHARMACODYNAMICS AND EFFECTS ON THE DAILY BLOOD PRESSURE PROFILE
    Olga D. Ostroumova,Elena A. Smolyarchuk,Olga V. Bondarec, Elena E. Paleeva
    Rational Pharmacotherapy in Cardiology（2017）
    The features of the pharmacokinetics of the angiotensin II receptor blocker telmisartan are considered. Thanks to these features it has a number of advantages in comparison with other angiotensin II receptor blockers and antihypertensive drugs from other classes. Particular atten...
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    Clinical and Laboratory Predictors of Major Adverse Cardiac Events in Patients with Ischemic Heart Disease Following Elective Percutaneous Coronary Intervention
    Elena Z. Golukhova,Marina V. Grigoryan,Mariya N. Ryabinina,Naida I. Bulaeva
    Rational Pharmacotherapy in Cardiology（2016）
    Background. Despite recent advances in stent design and constantly improving protective pharmacological strategies, complications and adverse events following percutaneous coronary interventions (PCI) are still major factors influencing morbidity and mortality. Therefore, predict...
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    Change of Cardiovascular Risk Factors and Quality of Life in Young Hypertensive Patients As A Result of Preventive Consultation in Primary Health Care
    M. I. Shupina
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2009）
    Aim. To evaluate changes of quality of life (QL) in young hypertensive patients having «Health School» educational course in comparison with patients having standard non-drug therapy.Material and methods. 114 young patients with arterial hypertension, stage 1, and low and moderat...
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    THE USE OF ENOXAPARIN IN ACUTE CORONARY SYNDROME
    Elena A. Smirnova,Sergey S. Yakushin
    Rational Pharmacotherapy in Cardiology（2016）
    The article discusses the choice of anticoagulant in different patterns of acute coronary syndrome (ACS). According to current recommendations three groups of agents are used as anticoagulants in ACS: unfractionated heparin (UFH) and low molecular weight heparin (LMWH), fondapari...
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    ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN MANAGEMENT OF PATIENTS WITH CHRONIC HEART FAILURE
    S. N. Tereshchenko,N. A. Dzhaiani
    Rational Pharmacotherapy in Cardiology（2009）
    The role of ACE inhibitors in modern pharmacotherapy of patients with chronic heart failure (CHF) is discussed. The actual usage of these highly effective drugs is underlined taking into account high prevalence and social significance of CHF. Necessity of ACE inhibitors usage is ...
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    Remodeling of the Pulmonary Circulation in Patients with Viral Liver Cirrhosis
    Marina Chistyakova,Anatoly Govorin, Yuri Parkhomenko
    Rational Pharmacotherapy in Cardiology（2019）
    Aim. To study some structural and functional indicators of the right heart, as well as the effect of antiviral therapy on these parameters in patients with viral liver cirrhosis (VLC). Material and methods . Patients with VLC (n=98; mean age 40.6 years, disease duration 3.9 years...
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    CLINICAL CASE OF THROMBOLYTIC THERAPY OF RECURRENT ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN PATIENT WITH LONG HISTORY OF ISCHEMIC HEART DISEASE
    N. T. Vatutin,V. B. Kostogryz, A. I. Kostogryz, O. I. Stolika
    Rational Pharmacotherapy in Cardiology（2016）
    Presented case report demonstrates the efficacy and safety of hospital use of thrombolytic agent Fortelizin in pharmaco-invasive strategy for the treatment of a patient with acute myocardial infarction and with a long history of ischemic heart disease and long-term dynamics of th...
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    Camellia Trial: Comparison in Therapies Based on Carvedilol and Metoprolol in Hypertensive Patients with Overweight and Obesity
    S. Y. Martsevich,N. P. Kutishenko
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2008）
    Therapy of arterial hypertension in patients with overweight and obesity has peculiarities. Reasons for comparable study of efficacy and safety of therapies based on β-blockers (carvedilol and metoprolol) in this type of patients are presented. Study aims and design, efficacy and...
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    LEFT ATRIAL FUNCTION: MODERN ASSESSMENT METHODS AND CLINICAL SIGNIFICANCE
    Elena N. Pavlyukova,Dmitry A. Kuzhel,Gennady V. Matyushin
    Rational Pharmacotherapy in Cardiology（2017）
    Assessment of the left atrial (LA) function is important aspect of comprehensive cardiovascular system estimation. Many cardiac diseases make an impact to LA work either by direct affect on myocardium or hemodynamic condition changing. It is considered, LA and left ventricle dias...
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    Systemic ATTR-amyloidosis, a Rare Form of Internal Organ Damage
    Vilen V. Rameev,Roman P. Myasnikov, Pavel P. Vinogradov,Lidiya Kozlovskaya,Sergei Moiseev,Ekaterina Fomicheva,Svetlana A. Beregovskaya,Elena A. Mershina, Svetlana A. Kostina,Leonid A. Strizhakov,Anna S. Rameeva,Pavel P. Tao,
    Rational Pharmacotherapy in Cardiology（2019）
    The article presents the case report of a rare hereditary form of systemic ATTR-amyloidosis in Russian patient with a discussion of approaches to the diagnosis and treatment of this form, also based on the own experience in the management of such patients. Modern ideas about the ...
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    Sleep Duration: Modern View of the Problem from the Standpoint of A Cardiologist
    O. M. Drapkina,R. N. Shepel
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2015）
    Today the role of disturbances in sleep duration in the development of various chronic diseases, including cardiovascular diseases is known and proven. In addition, the results of many clinical studies demonstrate the relationship between impaired sleep duration and the rate of t...
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    Medical Supervision in Specialized Center and the Quality of Lipid-Lowering Therapy in Patients with Cardiovascular Diseases (according to the Profil Register)
    S. Yu. Martsevich, O. V. Gaysenok,S. G. Tripkosh,A. V. Zagrebelnyy,Yu. V. Lukina
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2013）
    Aim. To assess the quality of lipid-lowering therapy in high risk patients with cardiovascular diseases during medical supervision in specialized center.Material and methods. The data of the PROFIL register are used. All patients having cardiovascular diseases, high cardiovascula...
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    A Prospective, Initiative, Single-Center Open Post-Registration Comparative Study of Laboratory Efficacy of Various Forms of Acetylsalicylic Acid in a Cardioprotective Dose with Different Composition of Excipients: Results of the SFAIROS Study
    Nikita Lomakin,Lyudmila Buryachkovskaya, Denis A. Zolin,Vasily Kazey
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY（2020）
    Aim. To compare the kinetics of dissolution (in vitro) and some pharmacodynamic and pharmacokinetic parameters of branded generic preparations of acetylsalicylic acid (ASA) in buffered form in cardioprotective doses [ASA 75 mg+Mg(OH)2 15.2 mg], which differ in the composition of ...
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