My laboratory is working on trying to understand how anovulation occurs in females since this is a major reproductive problem in women and in domestic livestock such as cows. We have identified a population of cows in our research herd that has excess androgens, has granulosa cell dysfunction that results in anovulation and a 17% reduction in calving rate. We also have identified how heifers in our herd attain puberty. We have developed mouse lines to investigate genes critical in fertility.