My research program is focused on translating basic science findings on the role of hypoxia in tumour progression and resistance to therapy to pre-clinical models of cancer that I ultimately hopes to take into the clinic. My overarching hypothesis is that hypoxia not only makes tumour cells resistant to radiotherapy, chemotherapy and in some cases targeted therapy, but also increases their invasiveness and metastatic potential by inducing a select group of genes involved in tissue remodeling.