My main interests are in the sequence, structure and function of antibodies, and in the effects of mutation on protein structure and function. We also develop widely-used software for Bioinformatics.

I have worked on the analysis and modelling of antibodies since my D.Phil. and developed the first automated modelling package for antibodies which was sold by Oxford Molecular. We have analysed and predicted the packing between light and heavy variable domains and developed measures of the 'humanness' of antibodies. More recently we have developed abYsis, an online database of pre-numbered antibody sequences and structures with analysis tools and abYmod, a new antibody modelling package.