Dr. Jaffe's research interests include a long academic career investigating the use of biomarkers to characterize the pathobiology of acute cardiovascular disease. With investigators at Washington University in St. Louis, he helped develop and was responsible for the validation studies of the first cardiac troponin I assay. His cutting-edge research explores questions surrounding many commonly used cardiac biomarkers. For that reason, he sits on most of the groups responsible for the implementation of guidelines in these areas. He has been one of the principles for the 4 iterations of the Universal Definition of MI.

Dr. Jaffe is a highly esteemed national and international presenter who has co-authored five books and written more than 1000 peer-reviewed articles, book chapters and abstracts. His writings particularly focus on the use of both cardiac troponin and natriuretic peptides to characterize patients with both acute and chronic heart failure. Dr. Jaffe has received many awards and honors throughout his career, including the Citation of International Service from the American Heart Association, the distinguished teacher award from the American College of Cardiology and the career achievement award for contributions to a specific area of laboratory medical from the American Association of Clinical Chemistry.