His areas of research and experience include spatially distributed hydrologic modeling, ecohydrology, spatial surface water balance modeling, sediment transport, surface and groundwater interactions modeling, spatial evapotranspiration mapping using remote sensing, water-energy-carbon fluxes coupling and modeling, remote sensing hydrology, climate change impact modeling, river basin management and land cover change detection and scaling. He has also worked on the application of artificial neural network and other statistical learning techniques to hydrology. He has vast experiences in the Nile River basin and the Caribbean islands. Dr. Melesse was a Fulbright Scholar in Ethiopia in 2012. Dr. Melesse has ample experience in river basin runoff modeling employing GIS and data from remote sensing.