Keppler's research activities are at the interface of inorganic chemistry and biology. A major focus of his activities is to understand, improve and develop anticancer drugs. He is a pioneer in investigating metal-based anticancer drugs and has developed multiple first-in-class compounds including KP1019, KP1339, and KP46 (IT-235, AP-002). BOLD-100, which is an anticancer drug related to the predecessors molecules KP1339 (NKP-1339, IT-139) and KP1019, is currently being investigated in clinical trials for advanced gastrointestinal cancers in combination with FOLFOX.[3] KP46 is currently being tested in patients with advanced solid tumors.[4] He also investigates environmental chemistry.