Osmoregulatory mechanisms of eukaryotes Blomberg has for a long time used genome-wide technologies, e.g. proteomics and phenomics, on the yeast Sacchaomyces cerevisiae to study salt stress and osmoregulatory mechanisms. These studies have resulted in the identification of genes involved in the production of the osmolyte glycerol (GPD1, GPP2), demonstrated the importance of N-terminal acetylation for specific stress proteins (TFS1) and provided a molecular understanding of salt stress-induced dihydroxyacetone toxicity (DAK1). We have also recently initiated studies of genes that are important in osmoregulation in the barnacle Balanus improvisus, via studies of e.g. the primary transporter Na+ / K+ ATPase, aquaporins and proline biosynthetic components. Salt-controlled genes in B. improvisus have been investigated via RNA sequencing and heterologous expression in yeast for functional characterization. We also conduct population-genomics and population-phenomics studies on the extremely salt-tolerant marine yeast Debaryomyces hansenii.