Hilbert Brendan J - Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School

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Papers共 29 篇Author StatisticsCo-AuthorSimilar Experts

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Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer

Benjamin C. Milgram, Deanna R. Borrelli,Natasja Brooijmans, Jack A. Henderson,Brendan J. Hilbert, Michael R. Huff, Takahiro Ito,Erica L. Jackson,Philip Jonsson,Brendon Ladd, Erin L. O'Hearn,Raymond A. Pagliarini, Simon A. Roberts, Sebastien Ronseaux,Darrin D. Stuart,Weixue Wang,Angel Guzman-Perez

JOURNAL OF MEDICINAL CHEMISTRY (2025)

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STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models

Raymond A Pagliarini, Jack A Henderson, Benjamin C Milgram, Deanna R Borrelli,Natasja Brooijmans,Brendan J Hilbert, Michael R Huff, Takahiro Ito,Gregory V Kryukov,Brendon Ladd, Brent R Martin, Hashim Motiwala, Erin O'Hearn, Chia-Feng Tsai, Weixue Wang, Justine Bellier, Luke Boland, Sarah Clark, Emily Hensley,Aaron N Hata,Petr Kuzmic,Angel Guzman-Perez, Erica L Jackson,Darrin D Stuart

Clinical cancer research an official journal of the American Association for Cancer Researchpp.OF1-OF17, (2025)

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DrugMap: A Quantitative Pan-Cancer Analysis of Cysteine Ligandability

Mariko Takahashi,Harrison B. Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J. Lazarov,Stefan Harry, Michelle Maynard,Brendan Hilbert, Ryan D. White, Heather E. Murrey, Chih-Chiang Tsou, Kira Vordermark, Jonathan Assaad,Magdy Gohar,Benedikt R. Durr,Marianne Richter,Himani Patel,Gregory Kryukov,Natasja Brooijmans, Aliyu Sidi Omar Alghali,Karla Rubio, Antonio Villanueva,Junbing Zhang,Maolin Ge, Farah Makram, Hanna Griesshaber, Drew Harrison, Ann -Sophie Koglin,Samuel Ojeda,Barbara Karakyriakou, Alexander Healy, George Popoola,Inbal Rachmin, Neha Khandelwal, Jason R. Neil, Pei-Chieh Tien,Nicholas Chen, Tobias Hosp, Sanne van den Ouweland,Toshiro Hara,Lillian Bussema,Rui Dong,Lei Shi,Martin Q. Rasmussen, Ana Carolina Domingues,Aleigha Lawless,Jacy Fang,Satoshi Yoda,Linh Phuong Nguyen, Sarah Marie Reeves, Farrah Nicole Wakefield,Adam Acker, Sarah Elizabeth Clark,Taronish Dubash, John Kastanos, Eugene Oh,David E. Fisher,Shyamala Maheswaran,Daniel A. Haber, Genevieve M. Boland,Moshe Sade-Feldman,Russell W. Jenkins,Aaron N. Hata, Nabeel M. Bardeesy,Mario L. Suva, Brent R. Martin,Brian B. Liau,Christopher J. Ott,Miguel N. Rivera,Michael S. Lawrence,Liron Bar-Peled

Cell（2024）

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Figure 5 from STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

Leonard Buckbinder,David J. St. Jean,Trang Tieu,Brendon Ladd,Brendan Hilbert,Weixue Wang,Jacob T. Alltucker,Samantha Manimala,Gregory V. Kryukov,Natasja Brooijmans, Gregory Dowdell,Philip Jonsson,Michael Huff,Angel Guzman-Perez,Erica L. Jackson,Marcus D. Goncalves,Darrin D. Stuart

openalex（2023）

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Figure 1 from STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

openalex（2023）

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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

Leonard Buckbinder,David J St Jean,Trang Tieu,Brendon Ladd,Brendan Hilbert,Weixue Wang,Jacob T Alltucker,Samantha Manimala,Gregory V Kryukov,Natasja Brooijmans,Gregory Dowdell,Philip Jonsson,Michael Huff,Angel Guzman-Perez,Erica L Jackson,Marcus D Goncalves,Darrin D Stuart

Cancer discoveryno. 11 (2023): 2432-2447

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Figure 6 from STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

openalex（2023）

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Figure 2 from STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

openalex（2023）

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Supplementary Tables and Figures from STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

openalex（2023）

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Figure 3 from STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

openalex（2023）

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