During research training in the Institute of Psychiatry in London, I developed and led a multidisciplinary clinical research study, the Maudsley Family Study of Psychosis, which identified endophenotypes of psychotic illness in genetically at risk relatives of patients. Since arriving to Galway I have developed a broad clinical research programme in psychiatry incorporating neuroscience and health services research projects and supervised numerous junior colleagues in projects related to these themes. A particular focus of the research programme is the application of structural neuroimaging to the understanding of the aetiopathogenesis of schizophrenia and bipolar disorder. To support this activity at NUIGalway, I developed, with Dr. Dara Cannon, the Clinical Neuroimaging Laboratory in 2006, and, with Prof. Gary Donohoe, the Centre for Neuroimaging and Cognitive Genomics in 2015.

I have strong collaborative links with multiple national and international partners and contribute clinical data and analyses to large collaborative genetics and neuroimaging consortia including Wellcome Trust Case Control Consortium, Psychiatric Genomics Consortium (PGC), Enhancing Neuroimaging Genetics though Meta-Analysis (ENIGMA), PSYSCAN.