Brian Mackness - University of Massachusetts Medical School

基本信息

Career Trajectory

Bio

I am a driven, hardworking and inquisitive individual with an interest in the relationship between protein folding and misfolding in human diseases. Leveraging biophysical approaches, we develop methods for targeting disease related proteins with small molecules to mitigate the formation of non-native conformations.

Research Interests

Papers共 17 篇Author StatisticsCo-AuthorSimilar Experts

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Learning the Language of Antibody Hypervariability

Rohit Singh, Chiho Im,Yu Qiu,Brian Mackness, Abhinav Gupta,Taylor Joren,Samuel Sledzieski, Lena Erlach,Maria Wendt,Yves Fomekong Nanfack,Bryan Bryson,Bonnie Berger

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA（2025）

Cited5Views0WOSBibtex

A Brain-Shuttled Antibody Targeting Alpha Synuclein Aggregates for the Treatment of Synucleinopathies

Sungwon An, John J. McInnis,Dongin Kim, Yihang Li, Ozge Yilmaz,Jinhyung Ahn,Brian C. Mackness, Jinyoung Park, Julia Maeve Bonner,Hyesu Yun, Simon Dujardin, Donghwan Kim, Seung-Hwan Kwon, Yi Tang,Laurent Pradier, Sumin Hyeon,Daehae Song,Byungje Sung, Rajaraman Krishnan,Brian Spencer,Robert Rissman, Jagdeeo Sandhu,Arsalan Haqqani, Hyeran Lee,Jinwon Jung,Weon-Kyoo You,Alexandra T. Star, Christine Delaney,Danica Stanimirovic,Sergio Pablo Sardi,Sang Hoon Lee,Can Kayatekin

biorxiv（2024）

Cited0Views0Bibtex

A Hydrophobic Core Stabilizes the Residual Structure in the RRM2 Intermediate State of the ALS-linked Protein TDP-43

Brian C. Mackness,Brittany R. Morgan,Laura M. Deveau,Sagar V. Kathuria,Jill A. Zitzewitz,Francesca Massi

JOURNAL OF MOLECULAR BIOLOGYno. 22 (2024)

Cited1Views0WOSBibtex

Mechanistic Incorporation of FcRn Binding in Plasma and Endosomes in a Whole Body PBPK Model for Large Molecules

de Witte Wilhelmus E. A.,Avery Lindsay B.,Mackness Brian C., Van Bogaert Tom,Park Anna, Sargentini-Maier Maria Laura

Journal of Pharmacokinetics and Pharmacodynamics（2023）

Cited4Views0WOSBibtex

Honing-in Antigen-Specific Cells During Antibody Discovery: a User-Friendly Process to Mine a Deeper Repertoire

Ankit Mahendra, Aftabul Haque,Ponraj Prabakaran,Brian C. Mackness, Thomas P. Fuller, Xiaohua Liu,Sagar V. Kathuria,Yui-Hsi Wang, Nilesh Amatya,Xiaocong Yu,Joern Hopke,Dietmar Hoffmann,Eva Bric-Furlong,Ningning Zhang,Hyun-Suk Cho, Ruijun Zhang,Jose Sancho,Jacqueline Saleh,Sambasiva P. Rao,Maria Wendt,Partha S. Chowdhury

Communications Biology（2022）

Cited4Views0WOSNATUREBibtex

A Platform-Agnostic, Function First-Based Antibody Discovery Strategy Using Plasmid-Free Mammalian Expression of Antibodies

Ruijun Zhang,Ponraj Prabakaran,Xiaocong Yu,Brian C. Mackness,Ekaterina Boudanova,Joern Hopke,Jose Sancho,Jacqueline Saleh,HyunSuk Cho,Ningning Zhang,Helene Simonds-Mannes,Samuel D. Stimple,Dietmar Hoffmann,Anna Park,Partha S. Chowdhury,Sambasiva P. Rao

mAbs（2021）

Cited6Views0WOSBibtex

Trifluoroethanol Partially Unfolds G93A SOD1 Leading to Protein Aggregation: A Study by Native Mass Spectrometry and FPOP Protein Footprinting

Ben Niu,Brian C. Mackness,Jill A. Zitzewitz,C. Robert Matthews,Michael L. Gross

Biochemistry（2020）

Cited8Views0WOSBibtex

Pharmacokinetics of Novel Fc-engineered Monoclonal and Multispecific Antibodies in Cynomolgus Monkeys and Humanized FcRn Transgenic Mouse Models

Delphine Valente,Christine Mauriac,Thorsten Schmidt,Ingo Focken,Jochen Beninga,Brian Mackness,Huawei Qiu,Pascale Vicat,Abdullah Kandira,Katarina Radosevic, Srini Rao, John Darbyshire,Mostafa Kabiri

mAbs（2020）

Cited16Views0WOSBibtex

Antibody Fc Engineering for Enhanced Neonatal Fc Receptor Binding and Prolonged Circulation Half-Life

Brian C. Mackness, Julie A. Jaworski,Ekaterina Boudanova,Anna Park,Delphine Valente,Christine Mauriac,Olivier Pasquier,Thorsten Schmidt,Mostafa Kabiri,Abdullah Kandira,Katarina Radosevic,Huawei Qiu

MABS（2019）

Cited72Views0WOSBibtex

Probing the Functional and Disease Consequences of Populating an RNA Recognition Motif Intermediate State, a Common Feature In a Set of Amyotrophic Lateral Sclerosis-Linked RNA-Binding Proteins

Brian Mackness,Jill Zitzewitz,Brian C. Mackness, Connor E. Maguire, Elizabeth M. DiLoreto, Lidette M. Angeles-Perez, Muska Hassan, Kevin O. Boettger,Selma Erendira Avendano-Vazquez,Brittany Morgan,C. Robert Matthews,Osman Bilsel,Francesca Massi,Jill A. Zitzewitz

PROTEIN SCIENCE（2018）

Cited0Views0Bibtex

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