Cécile Gauthier-Rouvière has an internationally recognized expertise in Cell Biology with a focus on cadherin-mediated cell adhesion, flotillin signaling and trafficking pathways. In the last years, her team has been working on the role of flotillins in cancer cell invasion. Flotillins 1 and 2 are proteins broadly upregulated in all tumor types, which is associated with a bad prognosis, and having a conserved role during metastasis development. We identified that upregulated flotillins derail the membrane traffic and elicite the UFIT (Upregulated Flotillins Induced Trafficking) pathway that promotes tumor cell invasion. The sphingolipids are key players of the UFIT pathway. Our discoveries could lead to propose inhibitors of the lipid metabolism as a therapeutic strategy for patients with flotillin-positive cancer.