Carl R. Walkley

I am interested in understanding the regulation of RNA and how this is important in normal development and cancer. It is now appreciated that RNA is actively regulated at many levels and this is important for the function both normal cells and in cancer. I am interested in how RNA editing by ADAR proteins changes the RNA landscape and contributes to normal physiology and cancer. I am also interested in why RNA splicing mutations are so important in the formation of blood cancers, in particular myelodysplastic syndrome. We use the models we generate to identify and develop new therapies for cancer.