Klaver is leading an international study on the influence of genes and the environment on four key abnormalities: myopia, AMD, retinal dystrophy and glaucoma, called The Rotterdam Study. She participates in a wide range of projects, such as Generation R, a longitudinal general health study of 10,000 children in Rotterdam, from early pregnancy onwards. She has instigated a number of epidemiological investigations herself, and has initiated a major international research project: Consortium on Refractive Error and Myopia (CREAM). Her work has resulted in groundbreaking insights in the field of macular degeneration, and looks to do similar with myopia.