His research activity is applied to different fields, including small scale biorobotics, actuators for compliant robots, biomechatronics and micromechatronics for medical applications. He received international recognitions for the development of novel actuators for microrobots and he has been visiting researcher at the University of Stanford, Center for Design Research, where he focused his activity on the issue of high-efficient, high performance mechanisms for bio-robotics.

Prof. Stefanini has been the project manager of two European Projects, the first one addressing new bioinspired robotic artefacts, the second one aimed at developing new high precision manufacturing technologies for flexible, cost efficient and eco-friendly mass production of complex shape parts at the micro/meso-scale level. Prof. Stefanini is also founder of a spin-off company active in the field of micro-scale energy and actuation.