Charles Auffray develops a systems approach to complex diseases, integrating functional genomics, mathematical, physical and computational concepts and tools. He is promoting open-access reagent, instrumentation and information platforms through public-private partnerships. He co-founded the IMAGE Consortium and the Systemoscope International Consortia with Profs Leroy Hood (Institute for Systems Biology, Seattle USA) and Zhu Chen (Center for Systems Biomedicine, Shanghai, China) to also tackle related epistemological, ethical, legal, philosophical and socio-economical issues with emphasis on interdisciplinarity and public education. At EISBM, Charles Auffray is fostering the transition from reactive to proactive Systems P4 Medicine through the Pioneers of Health and Wellness Vistera Project in partnership with ISB and a worldwide network of systems medicine centres.