His research interests include advanced medical information processing, and spatial, temporal and functional information modeling and analysis in medical images, with applications in various medical domains including orthopedics, gastroenterology ophthalmology, cardiology and nuclear medicine. He has published more than 200 papers, holds ten patents and is the cofounder of spin-off companies in orthopedic computer-assisted surgery.,Dr. Roux was an Associate Editor for the IEEE Transactions On Medical Imaging and the Chairman of its Steering Committee (1993–2003), member of the Editorial board of the IEEE Transaction On Information Technology and of the Proceedings Of The IEEE, and is a founding member of the Editorial Board of the IEEE Journal Of Biomedical and Health Informatics J-BHI. He is the founding cochairman of the IEEE EMBS International Summer School on Biomedical Imaging held every other year in France, which is now recognized as a worldwide reference. He served as President of the IEEE Engineering in Medicine and Biology Society in 2001. He played a seminal role in the creation of IEEE ISBI International Symposium on Biomedical Imaging in 2002. In 2004, he became a Senior Advisor with the French Ministry of Research and in 2006 Program Officer with the French National Research Agency in the area of Technologies for Health.