As a physician-epidemiologist, I am interested in reducing the suffering and mortality associated with infectious diseases, especially tuberculosis and HIV infection. I am committed to working in the regions of the world that are most afflicted by these diseases so my research and clinical activities focus on Sub-Saharan Africa, especially Uganda. My current research agenda is designed to improve current methods for tuberculosis control and to improve clinical care for tuberculosis among HIV-infected persons. My research has evaluated the mechanisms of the HIV-tuberculosis coinfection, treatments of HIV-associated tuberculosis, and prevention of tuberculosis. I have been continuously funded with federal grants since1993. My research portfolio includes household contacts studies, social network studies, large population-based cohort studies, and phase II and III randomized clinical trials, all conducted in Africa. I am an expert on study design and causal inference; I use modern quantitative methods for analysis of complex and large datasets.