His major research interests include clinical outcome registries, randomized controlled trials, and epidemiological cohort studies. He has over 650 peer-reviewed publications, many of which are in leading journals including the New England Journal of Medicine (9), Lancet (14), JACC (14) and JAMA. He has been Study Director for the 2nd Australian National Blood Pressure (ANBP2) Study and currently a Chief Investigator for the Aspirin in Reducing Events in the Elderly (ASPREE) Study, the Statins in Reducing Events in the elderly Trial and the Australian arms of the HOPE-3, REACH and CLARIFY Registries.