Research Interests
Drug discovery:

New strategies for peptide and protein drug development; peptide drug delivery; peptide and protein bioconjugates and antibody-drug conjugates as drug modalities; new peptide leads from phage display and natural sources.
Medicinal chemistry and structure-based drug design; peptidomimetics; combinatorial chemistry for drug lead discovery.
Development and use of peptide nucleic acid analogs as antisense and antigene agents.
Pharmacokinetic (PK) studies using LC-MS.


Peptide/protein chemistry and chemical biology:

Development of chemical/enzymatic peptide ligation methods and site-specific protein modification methods; use of protein chemical synthesis for the study of protein structure and functions; study of ubiquitin biology and structural biology using homogeneous chemically ubiquitinated proteins; study of chromatin structure and biology using semisynthetic histones carrying various PTMs.