My research interests include analysis and design of algorithms, computational molecular biology, parallel processing and computer aided engineering. Fifty of my papers are published in prestigious journals of computer science. In the past years, I have developed tools for multiple sequence alignments and evolutionary trees by using the concept of compact set and the technologies of approximation. Recently, I am developing tools that help enzyme biologist to search active sites. The functions of the new tools cover the sequence alignment and the consensus finding with structure information. For the comparative genomics, I design several different algorithms to predict exons and alternative splicing. I hope to develop tools for pathway verification by using the technologies of computing theory and computer aided engineering. I have plentiful experiences to lead the cooperation of computer scientists and biologists.