As Lead for Molecular Pathology within the Oxford Genomic Medicine Centre (the Genomics England / 100k Genome Project), I lead the pathology aspects of the project and am involved in operations for the ‘cancer’ part. Having been part of the BRC pilots for Genomics England, we successfully submitted batches of fresh frozen and formalin fixed paraffin embedded (FFPE) material for sequencing and are now starting to receive this data. We have also been optimising the formalin fixation protocols to maximise the chances of successfully obtaining good quality DNA from FFPE for whole genome sequencing. I have been involved in writing the national protocols for tissue handling for the 100k Genome Project.