A molecular and cell biologist by training, I study cell signalling in cancer. My current research focusses on understanding the molecular mechanisms that drive the progression to therapy-resistant, metastatic prostate cancer. A central theme of my research programme is the androgen receptor signalling cascade where my group has identified many critical epigenetic alterations that influence receptor function and created relevant cell models, including induced pluripotent stem cells. I have a number of ongoing biotech collaborations that involve the identification and assay development of biomarkers that distinguish indolent from aggressive prostate cancer.