Darrin Stuart - Scorpion Therapeutics

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Papers共 165 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer

Benjamin C. Milgram, Deanna R. Borrelli,Natasja Brooijmans, Jack A. Henderson,Brendan J. Hilbert, Michael R. Huff, Takahiro Ito,Erica L. Jackson,Philip Jonsson,Brendon Ladd, Erin L. O'Hearn,Raymond A. Pagliarini, Simon A. Roberts, Sebastien Ronseaux,Darrin D. Stuart,Weixue Wang,Angel Guzman-Perez

JOURNAL OF MEDICINAL CHEMISTRY (2025)

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STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models

Raymond A Pagliarini, Jack A Henderson, Benjamin C Milgram, Deanna R Borrelli,Natasja Brooijmans,Brendan J Hilbert, Michael R Huff, Takahiro Ito,Gregory V Kryukov,Brendon Ladd, Brent R Martin, Hashim Motiwala, Erin O'Hearn, Chia-Feng Tsai, Weixue Wang, Justine Bellier, Luke Boland, Sarah Clark, Emily Hensley,Aaron N Hata,Petr Kuzmic,Angel Guzman-Perez, Erica L Jackson,Darrin D Stuart

Clinical cancer research an official journal of the American Association for Cancer Researchpp.OF1-OF17, (2025)

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Abstract PO2-18-04: STX-478 is a Potentially Best-in-class Mutant-Selective PI3Kα Inhibitor That Demonstrates Robust Efficacy in ER+ Breast Cancer Models As Monotherapy and in Combination with Standard of Care Agents

Trang Tieu,Leonard Buckbinder, David St. Jean,Samantha Manimala,Gregory Dowdell,Michael Huff,Jacob Alltucker,Erica Jackson,Angel Guzman-Perez,Darrin Stuart

Cancer Research（2024）

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STX-478 is a Potentially Best-in-class Mutantselective PI3Ka Inhibitor That Demonstrates Robust Efficacy in ER Plus Breast Cancer Models As Monotherapy and in Combination with Standard of Care Agents

Trang Tieu,Leonard Buckbinder, David St Jean,Samantha Manimala, Gregory Dowdell,Michael Huff,Jacob Alltucker,Erica Jackson,Angel Guzman-Perez,Darrin Stuart

CANCER RESEARCHno. 9 (2024)

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Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science

Darrin D. Stuart,Angel Guzman-Perez,Natasja Brooijmans,Erica L. Jackson,Gregory V. Kryukov,Adam A. Friedman,Axel Hoos

Cancer Discoveryno. 10 (2023): 2131-2149

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Figure S1 from Distinct Transcriptional Programming Drive Response to MAPK Inhibition in BRAFV600-Mutant Melanoma Patient-Derived Xenografts

Tianshu Feng,Javad Golji,Ailing Li,Xiamei Zhang,David A. Ruddy,Daniel P. Rakiec,Felipe C. Geyer,Jane Gu,Hui Gao,Juliet A. Williams,Darrin D. Stuart,Matthew J. Meyer

openalex（2023）

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