Smith is best known for his theoretical and experimental work on electromagnetic metamaterials. Metamaterials are artificially structured materials, whose electromagnetic properties can be tailored and tuned in ways not easily accomplished with conventional materials. Smith has been at the forefront in the development of numerical methods to design and characterize metamaterials, and has also provided many of the key experiments that have helped to illustrate the potential that metamaterials offer. Smith and his colleagues at UCSD demonstrated the first left-handed (or negative index) metamaterial at microwave frequencies in 2000--a material that had been predicted theoretically more than thirty years prior by Russian physicist Victor Veselago. No naturally occurring material or compound with a negative index-of-refraction had ever been reported until this experiment. In 2001, Smith and colleagues followed up with a second experiment confirming one of Veselago's key conjectures: the 'reversal' of Snell's law. These two papers--the first published in Physical Review Letters and the second in Science--generated enormous interest throughout the community in the possibility of metamaterials to extend and augment the properties of conventional materials. Both papers have now been cited more than 3,000 times each.