Aspergillus fumigatus is an environmental mold that is responsible for life-threatening pulmonary infections. The fungus is a potent opportunistic pathogen that takes advantage of weakened immune systems to establish an infection. For this reason, patients with hematologic malignancies, or those receiving immunosuppressive therapies for the treatment of organ transplantation are most at risk for developing the disease. The mission of our laboratory is two-fold: (1) to identify the fungal pathways that allow A. fumigatus to thrive in the host environment and (2) to understand how the immune response protects against the infection. Our long-term goal is to provide a rational basis for the design of novel therapeutic strategies that can impair the growth of the of fungus during infection, thereby improving patient outcome.