David Twesigomwe - National Health Laboratory Service, and School of Pathology, University of the Witwatersrand

基本信息

Career Trajectory

Bio

David is currently doing his PhD in Human Genetics at Wits University. He is based at the Sydney Brenner Institute for Molecular Bioscience, where he is studying the variation in ADME genes in African populations as part of the H3A/GSK collaboration. Prior to joining Wits, David trained as a MUII-Plus strategic intern in Bioinformatics and Computational Biology for one year at the Uganda Virus Research Institute.

Research Interests

Papers共 29 篇Author StatisticsCo-AuthorSimilar Experts

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Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub-Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases

Thandeka V. B. Malinga,Houcemeddine Othman,Maria Paximadis,Caroline T. Tiemessen,Michele Ramsay,Scott Hazelhurst,David Twesigomwe

CLINICAL PHARMACOLOGY & THERAPEUTICS (2025)

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PharmVar GeneFocus: CYP2A6

Alec W R Langlois,Meghan J Chenoweth,David Twesigomwe,Giada Scantamburlo,Michelle Whirl-Carrillo,Katrin Sangkuhl,Teri E Klein,Charity Nofziger,Rachel F Tyndale,Andrea Gaedigk

Clinical pharmacology and therapeutics（2024）

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Nanopore Sequencing of 1000 Genomes Project Samples to Build a Comprehensive Catalog of Human Genetic Variation

Jonas A Gustafson,Sophia B Gibson,Nikhita Damaraju,Miranda Pg Zalusky,Kendra Hoekzema,David Twesigomwe,Lei Yang,Anthony A Snead, Phillip A Richmond,Wouter De Coster,Nathan D Olson,Andrea Guarracino, Qiuhui Li,Angela L Miller,Joy Goffena, Zachery Anderson, Sophie Hr Storz, Sydney A Ward, Maisha Sinha,Claudia Gonzaga-Jauregui,Wayne E Clarke,Anna O Basile,André Corvelo,Catherine Reeves,Adrienne Helland,Rajeeva Lochan Musunuri, Mahler Revsine,Karynne E Patterson,Cate R Paschal, Christina Zakarian,Sara Goodwin,Tanner D Jensen, Esther Robb, Genomes ONT Sequencing Consortium, University of Washington Center for Rare Disease Research (UW-CRDR), Genomics Research to Elucidate the Genetics of Rare Diseases (GREGoR) Consortium,W Richard McCombie,Fritz J Sedlazeck,Justin M Zook,Stephen B Montgomery,Erik Garrison,Mikhail Kolmogorov,Michael C Schatz,Richard N McLaughlin,Harriet Dashnow,Michael C Zody,Matt Loose,Miten Jain,Evan E Eichler,Danny E Miller

medRxiv the preprint server for health sciences (2024)

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Characterisation of CYP2D6, CYP2B6 and CYP2A6 Haplotype Variation in African Populations and Development of the StellarPGx Diplotype Calling Algorithm

David Twesigomwe,Zane Lombard,Scott Hazelhurst

EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 692-693

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Short-read Full-Length 16S Rrna Amplicon Sequencing for Characterisation of the Respiratory Bacteriome of Captive and Free-Ranging African Elephants (loxodonta Africana)

Lauren C. Martin, Michaela A. O'Hare,Giovanni Ghielmetti,David Twesigomwe,Tanya J. Kerr,Rachiel Gumbo,Peter E. Buss,Natasha Kitchin,Sian M. J. Hemmings,Michele A. Miller,Wynand J. Goosen

SCIENTIFIC REPORTS（2024）

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The Variation Landscape Ofcyp2d6in a Multi-Ethnic Asian Population

Yusuf Maulana, Rodrigo Toro Jimenez,David Twesigomwe,Levana Sani,Astrid Irwanto,Nicolas Bertin,Mar Gonzalez-Porta

SCIENTIFIC REPORTSno. 1 (2024)

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High-coverage Nanopore Sequencing of Samples from the 1000 Genomes Project to Build a Comprehensive Catalog of Human Genetic Variation

Jonas A. Gustafson,Sophia B. Gibson,Nikhita Damaraju,Miranda P. G. Zalusky,Kendra Hoekzema,David Twesigomwe, Lei Yang,Anthony A. Snead, Phillip A. Richmond,Wouter De Coster,Nathan D. Olson,Andrea Guarracino, Qiuhui Li,Angela L. Miller,Joy Goffena, Zachary B. Anderson, Sophie H. R. Storz, Sydney A. Ward, Maisha Sinha,Claudia Gonzaga-Jauregui,Wayne E. Clarke,Anna O. Basile,Andre Corvelo,Catherine Reeves,Adrienne Helland,Rajeeva Lochan Musunuri, Mahler Revsine,Karynne E. Patterson,Cate R. Paschal, Christina Zakarian,Sara Goodwin,Tanner D. Jensen, Esther Robb,William Richard McCombie,Fritz J. Sedlazeck,Justin M. Zook,Stephen B. Montgomery,Erik Garrison,Mikhail Kolmogorov,Michael C. Schatz,Richard N. McLaughlin Jr,Harriet Dashnow,Michael C. Zody,Matt Loose,Miten Jain,Evan E. Eichler,Danny E. Miller

GENOME RESEARCHno. 11 (2024): 2061-2073

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Characterization of CYP2B6 and CYP2A6 Pharmacogenetic Variation in Sub-Saharan African Populations

David Twesigomwe,Britt I. Droegemoeller,Galen E. B. Wright,Clement Adebamowo,Godfred Agongo,Palwende R. Boua,Mogomotsi Matshaba,Maria Paximadis,Michele Ramsay,Gustave Simo,Martin C. Simuunza,Caroline T. Tiemessen,Zane Lombard,Scott Hazelhurst

CLINICAL PHARMACOLOGY & THERAPEUTICS（2024）

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Characterization of CYP2C19 Pharmacogenetic Variation in African Populations and Comparison with Other Global Populations

Ross P. Booyse,David Twesigomwe,Scott Hazelhurst

Pharmacogenomics（2023）

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Characterizing the Combined Effects of Cytochrome P450 Missense Variation Within Star Allele Definitions

Nhlamulo Khoza,David Twesigomwe,Houcemeddine Othman

Pharmacogenomicsno. 10 (2023): 561-578

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