His research is interdisciplinary, integrative and collaborative and uses large-scale observational studies and randomised trials to generate reliable evidence for the prevention of premature deaths and disability from chronic diseases. Derrick's work involves applying statistical, epidemiological, computational, and genetic tools to understand associations of exposures with chronic diseases.

His research aims to drive improvements in population health by identifying novel treatment targets and implementing precision strategies for primary and secondary prevention of major disease outcomes such as cardiovascular disease, stroke, diabetes and cancer.