Over the past 30 years, he has conducted research in many areas of computational biology and bioinformatics, including single-cell data analysis, protein structure prediction and modeling, protein post-translational modifications, protein localization prediction, computational systems biology, biological information systems, and bioinformatics applications in human, microbes, and plants. His research since 2012 has focused on the interface between bioinformatics and deep learning. He has published more than 400 papers with more than 21,000 citations and an H-index of 73 according to Google Scholar. He was elected to the rank of American Association for the Advancement of Science (AAAS) Fellow in 2015 and American Institute for Medical and Biological Engineering (AIMBE) Fellow in 2020.