Douglas R Langbehn - University of Iowa

基本信息

Career Trajectory

Bio

1)Longitudinal observational studies healthy children and young adults who carry the Huntington's Disease trinucleotide expansion. 2) Design of Huntington's disease clinical trials. 3) Statistical consultant to the CHDI foundation

Research Interests

Papers共 255 篇Author StatisticsCo-AuthorSimilar Experts

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Challenges and Advances for Huntingtin Detection in Cerebrospinal Fluid: in Support of Relative Quantification

Rachel J. Harding,Yuanyun Xie, Nicholas S. Caron, Hailey Findlay-Black, Caroline Lyu,Nalini Potluri, Renu Chandrasekaran, Michael R. Hayden,Blair R. Leavitt,Douglas R. Langbehn,Amber L. Southwell

Biomarker Researchno. 1 (2025): 1-14

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Somatic CAG Repeat Expansion in Blood Associates with Biomarkers of Neurodegeneration in Huntington’s Disease Decades Before Clinical Motor Diagnosis

Nature Medicinepp.1-12, (2025)

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F040 Cognition in Far from Onset Young Adult Gene Expansion Carriers: Insights from the Huntington’s Disease Young Adult Study (HD-YAS)

Christelle Langley,Michela Leocadi,Mena Farag, Michael J Murphy,Rachael I Scahill,Nicola Z Hobbs,Kate Fayer,Olivia Thackeray,Edward J Wild,Geraint Rees,James Rowe,Douglas R Langbehn,Trevor W Robbins,Sarah J Tabrizi,Barbara J Sahakian

F Clinical studies case reports, observational studies and trials (2024)

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E018 Characterising the Earliest Neurodegenerative Changes in HD: Multi-Modal Neuroimaging Insights from the Huntington’s Disease Young Adult Study (HD-YAS)

Nicola Z Hobbs,Rachael I Scahill,Michela Leocadi, Michael J Murphy,Mena Farag,Christopher Parker,Kate Fayer,Olivia Thackeray, Hui Zhang,Edward J Wild,Douglas Langbehn,Sarah J Tabrizi

E Imaging (2024)

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J028 Preparing for Secondary Prevention Treatment Trials in HD-ISS Stages 0 and 1: Insights from the Huntington’s Disease Young Adult Study (HD-YAS)

J Clinical therapeutics (2024)

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F060 Characterisation of Neuropsychiatric Features in Young Adult Gene Expansion Carriers: Insights from the Huntington’s Disease Young Adult Study (HD-YAS)

Michela Leocadi,Christelle Langley,Mena Farag, Michael J Murphy,Rachael I Scahill,Nicola Z Hobbs,Kate Fayer,Olivia Thackeray,Edward J Wild,Geraint Rees,James Rowe,Douglas R Langbehn,Barbara J Sahakian,Sarah J Tabrizi

F Clinical studies case reports, observational studies and trials (2024)

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F044 Determining Clinically Meaningful Change on Cognitive Measures Used in Clinical Trials for Huntington’s Disease Using Function As an Anchor

Cali Roiboit,Douglas Langbehn,Julie Stout

F Clinical studies case reports, observational studies and trials (2024)

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F100 A Review of How Data from Enroll-HD Has Been Used to Advance Our Understanding of HD

Deborah Guest,Cristina Sampaio,John H Warner,Emily C Gantman,Alexandra Mansbach,Douglas Langbehn,James A Mills,Jatin G Vaidya,Jeffrey D Long,Swati Sathe

F Clinical studies case reports, observational studies and trials (2024)

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Mutant Huntingtin Drives Development of an Advantageous Brain Early in Life: Evidence in Support of Antagonistic Pleiotropy

Mohit Neema,Jordan L. Schultz,Douglas R. Langbehn,Amy L. Conrad,Eric A. Epping,Vincent A. Magnotta,Peggy C. Nopoulos

ANNALS OF NEUROLOGYno. 5 (2024): 1006-1019

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E021 Bias in HD-ISS Staging Introduced by Use of the Freesurfer Cross-Sectional Stream: Insights from the Hntington’s Disease Young Adult Study (HD-YAS)

Harry Knights,Annabelle Coleman,Nicola Hobbs, Michael Murphy,Mena Farag,Michela Leocadi,Kate Fayer,Olivia Thackeray,Douglas Langbehn,Rachael Scahill,Sarah Tabrizi

E Imaging (2024)

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