My laboratory pioneered methods to direct the evolution of enzymes, and we continue to refine and develop new approaches to protein engineering. Our most recent efforts combine directed evolution, simulation, and machine learning to optimize enzymes and create new ones. We have applied our techniques to an array of important problems in biocatalysis, from pharmaceutical synthesis to biofuels to sensors and diagnostics. We have also made key contributions to the understanding of enzyme evolution in nature. Our work has been recognized by numerous awards, including the 2018 Nobel Prize in Chemistry.