An early and major contribution of Dr. Labrie to clinical medicine was the discovery and development of medical castration with GnRH agonists as well as combined androgen blockade, the first treatment shown to prolong life in prostate cancer. Following his major contribution in prostate cancer, Dr. Labrie has shown that all androgens and all estrogens in women after menopause are made in peripheral tissues by the mechanisms of intracrinology from the inactive precursor dehydroepiandrosterone (DHEA). Dr. Labrie and his group also discovered the most potent antiestrogen, acolbifene, for the prevention and treatment of breast cancer.