New and remarkable interactions between light and matter arise in sufficiently intense optical fields, including the generation of new frequencies of light and the simultaneous absorption of multiple photons. At the core, our research group is devoted to the theoretical development and experimental application of new instrumental methods taking advantage of unique nonlinear optical interactions. Recent interests include detection and analysis of crystals formed from chiral molecules, building on a long-standing interest in understanding the role of chirality and polarization-dependent effects in nonlinear optics.