Graeme C Freestone - Department of Medicinal Chemistry, Ionis Pharmaceuticals

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Papers共 13 篇Author StatisticsCo-AuthorSimilar Experts

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Conjugation to a Transferrin Receptor 1-Binding Bicycle Peptide Enhances ASO and Sirna Potency in Skeletal and Cardiac Muscles

Michael E Østergaard,Michele Carrer,Brooke A Anderson, Megan Afetian, Mohsen A Bakooshli, Jinro A Santos, Stephanie K Klein, Juliana Capitanio,Graeme C Freestone,Michael Tanowitz, Rodrigo Galindo-Murillo, Hans J Gaus, Chrissa A Dwyer, Michaela Jackson, Paymaan Jafar-Nejad,Frank Rigo,Punit P Seth, Katherine U Gaynor, Steven J Stanway, Liudvikas Urbonas, Megan A St Denis, Simone Pellegrino, Gustavo A Bezerra,Michael Rigby, Ellen Gowans, Katerine Van Rietschoten,Paul Beswick,Liuhong Chen, Michael J Skynner,Eric E Swayze

Nucleic acids researchno. 7 (2025)

Cited0Views0WOSBibtex

Towards Combining Backbone and Sugar Constraint in 3′-3′ Bis-Phosphonate Tethered 2′-4′ Bridged LNA Oligonucleotide Trimers

Edouard Duchamp,Guillermo Vasquez, Neda Firoozi,Graeme C. Freestone,Michael Oestergaard,Punit P. Seth,Stephen Hanessian

RSC Advances（2024）

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Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA

Tamilselvan Rajasekaran,Graeme C. Freestone,Rodrigo Galindo-Murillo,Barbara Lugato,Hans Gaus,Michael T. Migawa,Eric. E. Swayze,Thomas E. Cheatham III,Punit P. Seth,Stephen Hanessian

The Journal of Organic Chemistry（2023）

Cited4Views0WOSBibtex

Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA

Tamilselvan Rajasekaran,Graeme C. Freestone,Rodrigo Galindo-Murillo,Barbara Lugato,Lorena Rico,Juan C. Salinas,Hans Gaus,Michael T. Migawa,Eric E. Swayze,Thomas E. Cheatham,Stephen Hanessian,Punit P. Seth

Journal of the American Chemical Society（2022）

Cited8Views0WOSBibtex

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′-O-methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

Lingdi Zhang,Xue-hai Liang,Cheryl Li De Hoyos, Michael Migawa,Joshua G. Nichols,Graeme Freestone,Jun Tian,Punit P. Seth,Stanley T. Crooke

Nucleic Acid Therapeutics（2022）

Cited10Views0WOSBibtex

Site-specific Incorporation of 5-Methyl DNA Enhances the Therapeutic Profile of Gapmer ASOs

Guillermo Vasquez,Graeme C. Freestone,W. Brad Wan,Audrey Low,Cheryl Li De Hoyos,Jinghua Yu,Thazha P. Prakash,Michael E. Ostergaard,Xue-hai Liang,Stanley T. Crooke,Eric E. Swayze,Michael T. Migawa,Punit P. Seth

Nucleic Acids Research（2021）

Cited30Views0WOSBibtex

Dipyrazolopyridines As Modulators Of Alpha 5 Containing Gaba(A) Receptors

Varsha Gupta, Joel I. Renick,Graeme C. Freestone,Nahid Yazdani,Jenny Wen,Kavitha Sugunan,Scott S. Downing,Terrell T. Gibbs,David H. Farb,Alan P. Kaplan

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2011)

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