His earlier research interests included theoretical computer science and semantics of programming languages. In the last decade, his research has revolved around Human-Data Interaction (HDITM), achieved through the development of innovative software and web-based applications spanning the biomedical data lifecycle. Software tools include query interface for clinical research, data management software for clinical trials and biomedical research, and tools for multi-site data integration. He led the development of data infrastructures and manages data resources, following the vision of NIH Data Commons, for the National Sleep Research Resource and for Center for Sudden Unexpected Death in Epilepsy Research, largest and most comprehensive, well-annotated clinical data sets in the two disease areas. He also has a track record of research in biomedical metadata including ontologies and terminology systems, to bring them to bear on HDI. Dr. Zhang effectively brings cutting-edge computer science and informatics methodology to addressing biomedical data/big data challenges through the translation of theory, algorithms, methods and best practices to functional and usable tools impacting the clinical research data lifecycle.