Guozhen Gao - College of Life Sciences, Wuhan University

基本信息

Career Trajectory

Bio

Guozhen Gao currently works at the Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center. Guozhen used to work on Virology and now switched his focus on Epigenetics, using methods from Molecular Biology and Cell Biology. Their current project is 'PRMT enzyme biology.'

Research Interests

Papers共 16 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Inhibition of PRMT5 Moderately Suppresses Prostate Cancer Growth in Vivo but Enhances Its Response to Immunotherapy

Qinju He, Yuanzhen Zhang,Wenchao Li,Saisai Chen,Jiangling Xiong,Ruizhe Zhao,Kai Yuan,Qiang Hu,Song Liu,Guozhen Gao,Mark T. Bedford,Dean G. Tang,Bin Xu,Cheng Zou,Dingxiao Zhang

Cancer Letterspp.217214-217214, (2024)

Cited1Views0WOSBibtex

PRMT5-Exacerbating Tumor Stemness and Immunosuppression Confer a Novel Therapeutic Vulnerability in Aggressive Prostate Cancer

Cheng Zou,Saisai Chen, Yuanzhen Zhang,Qinju He,Jiangling Xiong,Wenchao Li, Kai Wang,Ruifang Liu,Lingjing He,Amanda Tracz,Ruizhe Zhao,Kai Yuan,Qiang Hu, Song Liu,Guozhen Gao,Mark T. Bedford,Dean G. Tang,Bin Xu,Dingxiao Zhang

crossref（2023）

Cited0Views0Bibtex

The NFIB/CARM1 Partnership is a Driver in Preclinical Models of Small Cell Lung Cancer

Guozhen Gao,Simone Hausmann,Natasha M. Flores,Ana Morales Benitez,Jianjun Shen,Xiaojie Yang,Maria D. Person,Sitaram Gayatri,Donghang Cheng,Yue Lu,Bin Liu,Pawel K. Mazur,Mark T. Bedford

Nature Communications（2023）

Cited19Views0WOSNATUREBibtex

SPINDOC Binds PARP1 to Facilitate PARylation

Fen Yang,Jianji Chen,Bin Liu,Guozhen Gao,Manu Sebastian,Collene Jeter,Jianjun Shen,Maria D. Person,Mark T. Bedford

Nature Communications（2021）

Cited12Views0WOSNATUREBibtex

Genetic Evidence for Partial Redundancy Between the Arginine Methyltransferases CARM1 and PRMT6

Donghang Cheng,Guozhen Gao,Alessandra Di Lorenzo,Sandrine Jayne,Michael O. Hottiger,Stephane Richard,Mark T. Bedford

Journal of Biological Chemistry（2020）

Cited28Views0WOSBibtex

CARM1 Inhibition Reduces Histone Acetyltransferase Activity Causing Synthetic Lethality in CREBBP/EP300-mutated Lymphomas

Kylee J. Veazey,Donghang Cheng,Kevin Lin,Oscar D. Villarreal,Guozhen Gao,Mabel Perez-Oquendo,Hieu T. Van,Sabrina A. Stratton,Michael Green,Han Xu,Yue Lu,Mark T. Bedford, Margarida Almeida Santos

Leukemia（2020）

Cited34Views0WOSNATUREBibtex

Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders

Yudao Shen,Guozhen Gao,Xufen Yu,Huensuk Kim,Li Wang,Ling Xie,Megan Schwarz,Xian Chen,Ernesto Guccione,Jing Liu,Mark T. Bedford,Jian Jin

Journal of Medicinal Chemistry（2020）

Cited69Views0WOSBibtex

PRMT1 Loss Sensitizes Cells to PRMT5 Inhibition

Guozhen Gao,Liang Zhang,Oscar D. Villarreal,Wei He,Dan Su,Ella Bedford, Phoebe Moh,Jianjun Shen,Xiaobing Shi,Mark T. Bedford,Han Xu

Nucleic Acids Research（2019）

Cited70Views0WOSBibtex

Genetic Deletion or Small-Molecule Inhibition of the Arginine Methyltransferase PRMT5 Exhibit Anti-Tumoral Activity in Mouse Models of MLL -Rearranged AML

S Kaushik, F Liu,K J Veazey,G Gao,P Das, L F Neves, K Lin, Y Zhong, Y Lu, V Giuliani,M T Bedford,S D Nimer,M A Santos

Leukemia（2017）

Cited66Views0WOSNATUREBibtex

Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2

Jieqiong Zhou,Guozhen Gao,Panpan Hou,Chun-Mei Li,Deyin Guo

Journal of Cellular Biochemistry（2017）

Cited2Views0WOSBibtex

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