Major Research Interests

Modern mass-spectrometric methods have become key technologies in the life sciences. We apply “state-of-the-art” mass spectrometry to elucidate quantitative changes of proteins and their post-translational modifications derived from different samples, including tissue, cells, organelles, and cell compartments. In addition, we apply mass spectrometric (MS) methods to monitor dynamic changes of protein and protein-ligand complexes through use of cross-linking. Following main projects are investigated by the use of MS are: 1. Monitoring protein abundance, modifications and interactions in the non-stimulated and stimulated synapse by MS, 2. Protein-protein cross-linking combined with MS in stimulated and resting B cells, 3. Method development in protein-protein, protein-RNA and protein-DNA cross-linking combined with MS.