Over 35 years of drug discovery experience in five therapeutic areas including neuroscience, oncology, infectious diseases, metabolic diseases and cardiovascular diseases, delivering multiple clinical candidates for clinical development; inventor of two HIV drugs at Abbott Laboratories (Norvir and Kaletra, both HIV Protease inhibitors) that were approved by the FDA and EMEA, with one of them (Kaletra) having blockbuster sales (over a billion dollars per year) every year since 2005. Named National Inventor of the Year in 1997 by Intellectual Property Owners-Washington DC; named Inventor of the year two times by the Intellectual Property Law Association of Chicago (1997 & 2004); named Hero of Chemistry by the American Chemical Society in 2003 for the invention of Kaletra. Named the 2011 Distinguished Alumni by the University of Hawaii Alumni Association. Recipient of K. Fong Award from Chinese American Biopharmaceuticals Society in 2014 (co-recipient, Dr Ge Li of WuXi).