A major focus of his research is on diseases affecting the vascular system, the placenta, and early brain development. He has employed mouse models of disease in combination with advanced imaging technologies to understand how early life adversity affects fetal and post-natal development and, in particular, the brain. Dr. Sled is widely recognized for his contributions to the development of medical imaging technologies. He was the first to describe comprehensive quantitative magnetization transfer MRI in humans and is the author of the widely used neuroimaging software N3. He has also made contributions in the areas of MRI relaxometry, tissue microstructure / diffusion, perfusion, and morphometric techniques.