Jan Veldink’s research focuses on identifying genes underlying neurological disorders, particularly ALS. His work includes diverse studies, ranging from investigations in well-defined families to large-scale cohorts of patients and controls in search of risk genes. He employs cutting-edge research techniques such as genome-wide association studies (GWAS), DNA sequencing, and RNA sequencing. Currently, he leads the world’s largest whole-genome sequencing project for ALS: Project MinE. In 2016, he discovered two new ALS risk genes, NEK1 and C21orf2, and clarified the genetic architecture of ALS.