At UT Southwestern, Dr. Fleming directs all clinical operations at the Simmons Comprehensive Cancer Center (SCCC) and drives strategies to advance innovative, patient-centered cancer care across the health system. His goal is to promote and further establish SCCC as a national leader in multidisciplinary, evidence-based patient care, cancer clinical trials, and novel treatment approaches.

He is a prolific academician, with over 300 peer-reviewed publications and contributions to numerous books. He has delivered many international, national, and regional invited lectures. He serves as principal investigator or co-investigator for numerous active research projects, with grant support from sources such as the National Institutes of Health, the National Cancer Institute, and the U.S. Army Medical Research Acquisition Activity’s Pancreatic Cancer Research Program.

Dr. Fleming is a Fellow of the American College of Surgeons and a member of numerous other professional organizations, including the American Society of Clinical Oncology, the Society of Surgical Oncology, and the American Association for Cancer Research. He also serves on the editorial board for the journal Surgery Open Science and serves as an ad hoc reviewer for other scholarly journals.

The recipient of numerous awards, he has been named a Castle Connolly Top Doctor every year since 2013.