Our studies are focused on sensory transduction and transmission in the peripheral nervous system, especially in pain signalling. We use gene targeting in and transgenic mice as a model, combining molecular biochemistry, electrophysiology and behavioural approaches to identify the genes or molecules involved and to understand the molecular, cellular, physiological and pathological mechanisms involved.
We have three main areas of research:
trafficking of sodium channel Nav1.7
BDNF in pain signalling,
microRNAs in pain signalling