His interests include the clinical and translational research of sarcomas, the direct care of patients with sarcoma, and education about sarcoma and patient-oriented research. As Associate Director for Clinical Research, his goal is to help Sylvester faculty develop clinical trials that provide clinically effective and scientifically exciting therapy to patients with cancer. The major efforts of Dr Trent’s research focus on understanding the mechanisms of action and resistance of imatinib in GIST and other sarcomas while striving toward improved therapeutic options. His work involves the use of novel preoperative/postoperative clinical trials, prospectively acquired tumor tissue, cell lines, and archival tissue.