Jonathan P Hutchinson - GlaxoSmithKline

基本信息

Career Trajectory

Bio

Experimental enzymologist with extensive industrial experience in drug discovery. Strong track record in mechanistic evaluation of enzymes and inhibitors, biochemical assay development and lead generation, and leadership of early stage discovery programmes

Research Interests

Papers共 19 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design

Ross P. Hryczanek, Andrew S. Hackett,Paul Rowland,Chun-wa Chung,Maire A. Convery,Duncan S. Holmes,Jonathan P. Hutchinson,Semra Kitchen,Justyna Korczynska,Robert P. Law, Jonathan D. Lea,John Liddle, Richard Lonsdale,Margarete Neu, Leng Nickels,Alex Phillipou,James E. Rowedder, Jessica L. Schneck,Paul Scott-Stevens, Hester Sheehan, Chloe L. Tayler,Ioannis Temponeras,Christopher P. Tinworth,Ann L. Walker,Justyna Wojno-Picon,Robert J. Young, David M. Lindsay,Efstratios Stratikos

ACS MEDICINAL CHEMISTRY LETTERSno. 12 (2024): 2107-2114

Cited0Views0WOSBibtex

A High-Throughput MALDI-TOF MS Biochemical Screen for Small Molecule Inhibitors of the Antigen Aminopeptidase ERAP1

Leonie Muller,Amy K. Burton, Chloe L. Tayler,James E. Rowedder,Jonathan P. Hutchinson, Simon Peace, Julie M. Quayle,Melanie Leveridge,Roland S. Annan,Matthias Trost,Rachel Peltier-Heap,Maria Emilia Duenas

SLAS DISCOVERY（2022）

Cited7Views0WOSBibtex

Common Allotypes of ER Aminopeptidase 1 Have Substrate-Dependent and Highly Variable Enzymatic Properties

Jonathan P. Hutchinson,Ioannis Temponeras,Jonas Kuiper,Adrian Cortes,Justyna Korczynska,Semra Kitchen,Efstratios Stratikos

Journal of Biological Chemistry（2021）

Cited21Views0WOSBibtex

The TAB1-p38α Complex Aggravates Myocardial Injury and Can Be Targeted by Small Molecules

Gian F. De Nicola,Rekha Bassi,Charlie Nichols,Mariana Fernandez-Caggiano,Pelin Arabacilar Golforoush,Dibesh Thapa,Rhys Anderson,Eva Denise Martin,Sharwari Verma,Jens Kleinjung,Adam Laing,Jonathan P. Hutchinson,Philip Eaton,James Clark,Michael S. Marber

JCI INSIGHT（2018）

Cited16Views0WOSBibtex

Structural and Mechanistic Basis of Differentiated Inhibitors of the Acute Pancreatitis Target Kynurenine-3-monooxygenase

Jonathan P. Hutchinson,Paul Rowland,Mark R. D. Taylor,Erica M. Christodoulou,Carl Haslam,Clare I. Hobbs,Duncan S. Holmes,Paul Homes,John Liddle,Damian J. Mole,Iain Uings,Ann L. Walker,Scott P. Webster,Christopher G. Mowat,Chun-wa Chung

Nature Communications（2017）

Cited39Views0WOSNATUREBibtex

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