The Li lab studies the genetic and functional basis of complex human diseases using genomic approaches. Currently our NIH-supported projects include the analyses of spontaneous mutation patterns in the human genome (NIGMS R01), multi-omic studies of a genetic rat model of addiction behavior (NIDA U01) and a rat model of metabolic health (NIDDK R01). We are part of the MoTrPAC Consortium (U24 NIH Common Funds) which seeks to discover the molecular transducers of the health benefit of physical exercise. Dr. Li co-directs the Michigan Center for Single-Cell Genomic Data Analytics, which aims to build a strong computational infrastructure to support the rigorous use of single-cell genomic data. An overarching theme in the Li lab is the responsible use of complex data in transparent, reproducible, and community extendable research. We are constantly recruiting talented individuals with background in biostatistics and biomedical data science.