We study surgical treatments for cases in which conventional surgery has been ineffective. Our research theme includes cardiac regeneration using human iPS cell-derived cardiac tissue sheets, prevention of complications related to cardiopulmonary bypass, development of surgical devices, phenotype control of vascular grafts using microRNAs, and development of decellularized vascular xenograft. We are preparing a clinical study of cardiac regenerative therapy for severe heart failure using human iPS cell-derived cardiac tissue as translational research. We also conduct observational studies from a registry database of patients undergone cardiovascular surgery from our affiliated institutes nationwide.