Konrad Krzewski

My research has focused on regulation of cytolytic activity of NK cells. I am interested in lysosome/lytic granule biogenesis, regulation of NK cell immune synapses, as well as impairment of NK cell function caused by lysosomal disorders. This relates to the involvement and role of NK cells in the parthenogenesis of several lysosome storage disorders with immunodeficiency, such as Chediak-Higashi syndrome, Hermansky-Pudlak syndrome, and familial hemophagocytic lymphohistiocytosis.