Professor Sandhoff’s major research interests are focused on molecular life sciences including the analysis and pathobiochemistry of lysosomal (glyco-) sphingolipid storage diseases, the structure and function of lysosomal enzymes and lipid binding proteins, the topology of endocytosis and glycolipid metabolism, and regulation of glycolipid biosynthesis. He has published more than 480 peer-reviewed papers, and has received more than 15 renowned national and international awards. Professor Sandhoff’s early investigation and analysis led to the identification of several biochemically distinct lysosomal diseases, including a variant of GM2-Gangliosidosis which was named Sandhoff disease in 1971.