Dr. Dupuis' work has far reaching impact on the health and quality of life of children with cancer. She has used the results of her research to develop clinical practice guidelines regarding treatment-related symptom prevention and management that have been endorsed by the Pediatric Oncology Group of Ontario (POGO), the Children’s Oncology Group and groups in several other jurisdictions. Dr. Dupuis has also developed and validated important symptom-screening tools, such as the Symptom Screening in Pediatrics (SSPedi) tool, which evaluates 15 symptoms important for children with cancer, and the Pediatric Nausea Assessment Tool (PeNAT), which has changed the way clinicians evaluate nausea severity, a symptom important to patients and parents. Dr. Dupuis is evaluating these tools for routine use in clinical practice and is studying the implementation of clinical care guidelines to address treatment-related symptoms in pediatric oncology centres.